Paper Details

Name: Bahareh Farasati Far, Ali Aghajani Shahrivar, Hazha Omar Othman, Mehdi Shafiee Ardestani, Hamidreza Pazoki Toroudi
Email: pazoki1970@gmail.com
Country: India

Year: 2021
Volume: Volume-8, Issue-1 (Jan-June)
DOI: http://doi.org/10.5281/zenodo.5118342

COVID-19, a pandemic affecting virus, which is caused by the current SARS-CoV2 coronavirus. The present research is performed on anti-virus and immune-modulating therapies. Cytokine storms are the toxic drivers and mortality caused by various human viral infections. In addition, the intensity was linked to an elevated risk of acute respiratory failure, myocardial injury, and mortality in SARS-CoV-2-infected patients. The Janus kinase (JAK) therapeutic inhibitor class showed significant clinical benefits in anti-inflammatory and anti-viral effects. Among them, filgotinib has been approved as an active JAK inhibitor by decreasing biomarkers with main immune reaction functions and markers supporting matrix-degradation, angiogenesis, leukocyte adhesion, and recruitment in both research trials. In this study, we tried to get an insight into the choice of this drug in controlling the jack to treat COVID-19 using drug design methods.