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Peer-Reviewed Open Access Publication · ISSN: 2321-8681 · CC-BY 4.0 International

Open Access ISSN: 2321-8681 Volume-7, Issue-1 (Jan-June) 2020

Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection (Pg: 60-67)

Authors: Arun Dev Sharma, Inderjeet Kaur India
Correspondence: arundevsharma47@gmai.com
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Abstract

COVID-19, a member of corona virus family is spreading its tentacles
across the world due to lack of drugs at present. However, the main
viral proteinase (Mpro/3CLpro) has recently been regarded as a
suitable target for drug design against SARS infection due to its vital
role in polyproteins processing necessary for coronavirus
reproduction. The present in silico study was designed to evaluate
the effect of Jensenone, a essential oil component from eucalyptus oil,
on Mpro by docking study. In the present study, molecular docking
studies were conducted by using 1-click dock and swiss dock tools.
Protein interaction mode was calculated by Protein Interactions
Calculator.The calculated parameters such as binding energy, and
binding site similarity indicated effective binding of Jensenone to
COVID-19 proteinase. Active site prediction further validated the
role of active site residues in ligand binding. PIC results indicated
that, Mpro/ Jensenone complexes forms hydrophobic interactions,
hydrogen bond interactions and strong ionic interactions. Therefore,
Jensenone may represent potential treatment potential to act as
COVID-19 Mpro inhibitor. However, further research is necessary to
investigate their potential medicinal use.

Journal Research and Reviews in Biotechnology and Biosciences
Peer Review Double-Blind Peer Reviewed
Publication Year 2020
Volume Volume-7, Issue-1 (Jan-June)
DOI doi.org/10.5281/zenodo.3748477
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Arun Dev Sharma, Inderjeet Kaur (2020 ). Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection (Pg: 60-67). Research and Reviews in Biotechnology and Biosciences, Volume-7, Issue-1 (Jan-June). https://doi.org/doi.org/10.5281/zenodo.3748477
Arun Dev Sharma, Inderjeet Kaur, 2020 . Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection (Pg: 60-67). Research and Reviews in Biotechnology and Biosciences, Volume-7, Issue-1 (Jan-June).
Arun Dev Sharma, Inderjeet Kaur. "Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection (Pg: 60-67)." Research and Reviews in Biotechnology and Biosciences Volume-7, Issue-1 (Jan-June) (2020 ).
@article{rrbb_136_ArunDevS, title = {{Jensenone from eucalyptus essential oil as a potential inhibitor of COVID 19 corona virus infection (Pg: 60-67)}}, author = {Arun Dev Sharma, Inderjeet Kaur}, journal = {Research and Reviews in Biotechnology and Biosciences}, issn = {2321-8681}, year = {2020 }, volume = {Volume-7, Issue-1 (Jan-June)}, doi = {doi.org/10.5281/zenodo.3748477} }
This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (CC-BY 4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source.