Paper Details

Name: Dr. Shivani Sharda
Email: ssharda@amity.edu
Country: India

Year: 2020
Volume: Volume-7, Issue-1 (Jan-June)
DOI: doi.org/10.5281/zenodo.3727372

Let‟s play lego game of blocks on life biomolecules, can we? Yes we can, that‟s what is the era of translational world of science, where synthetic biology envisions to build novel patterns of cellular function from the available blocks by engineering designs on the biological blocks - DNA and protein. The blocks here are the sequence components that are characterized in their most simple forms and then anchored together as a string of co-regulated genetic parts with desired functions. Synthetic biology dwells on high-throughput biological engineering and rational redesigning of biological substrates that have intricate but partially characterized details posing their unique set of challenges. The conceptual biological engineering includes design patterns, genetic or DNA components as libraries, computational tools for design, circuit design scaffolds, with the final aim of application specific designs. These synthetic genetic circuits possess the capacity to manipulate and probe biological interfaces. The comprehensive review aims to shed light on the progress, challenges and applications of key areas where synthetic biology is impacting biological sciences.