Research & Reviews in Biotechnology and Biosciences Journal

Archives Volume: 13, Issue: 1, (January-June)

Paper Title:: STRUCTURAL AND MORPHOLOGICAL ANALYSIS OF GALLIUM OXIDE
Author Name:: Aysha Praveen Ansari & Rekha Rikhari
Author Email:: fos.rekha@mhu.edu.in
Country:: India
DOI:: https://doi.org/10.5281/zenodo.18240136
Page No.:: 1-6

STRUCTURAL AND MORPHOLOGICAL ANALYSIS OF GALLIUM OXIDE

Author: Aysha Praveen Ansari & Rekha Rikhari

ABSTRACT
Gallium oxide (Ga2O3) is a renowned semiconductor for its high band gap. Its strong surface sensitivity, chemical stability and thermal strength make it a promising candidate for sensors, power electronics, and UV detectors. To support these applications, the structural and morphological properties of Ga2O3 were investigated using scanning electron microscopy (SEM) and X ray diffraction (XRD). SEM analysis revealed a highly agglomerated morphology consisting of uneven, submicron-sized primary particles with coarse surface textures, indicating a large surface area and enhanced surface reactivity. XRD patterns confirmed the formation of the monoclinic β-
Ga2O3 phase, with sharp and intense diffraction peaks demonstrating high crystallinity and phase purity. Collectively, these results confirm the successful synthesis of highly crystalline Ga2O3 and highlight its potential for high temperature electronics, sensing platforms, optoelectronic
devices, and catalytic applications.

Keywords: Gallium Oxide; Semiconductor; Structural analysis

Paper Title:: BIOMEDICAL SIGNIFICANCE OF COORDINATION COMPOUNDS IN MODERN THERAPEUTICS
Author Name:: Deep Narayan Maurya, Vandana & Manoj Kumar Parjapati
Author Email:: mauryadeep343@gmail.com
Country:: India
DOI:: https://doi.org/10.5281/zenodo.18466974
Page No.:: 7-15

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BIOMEDICAL SIGNIFICANCE OF COORDINATION COMPOUNDS IN MODERN THERAPEUTICS

Author: Deep Narayan Maurya, Vandana & Manoj Kumar Parjapati

ABSTRACT
Coordination compounds play a pivotal role in modern therapeutics due to their unique structural diversity, tunable reactivity, and ability to interact selectively with biological targets. In recent decades, advances in coordination chemistry have significantly expanded their biomedical applications, particularly in diagnosis, drug delivery, and treatment of complex diseases. Metal-based coordination compounds such as platinum, gold, copper, iron, and ruthenium complexes have demonstrated remarkable efficacy as anticancer, antimicrobial, anti-inflammatory, and antiviral agents. Their mechanisms of action often involve DNA binding, enzyme inhibition, redox activity, and modulation of cellular signaling pathways. Additionally, coordination compounds have been extensively explored in medical imaging, where metal complexes serve as contrast agents in techniques such as magnetic resonance imaging (MRI) and radiotherapy. The incorporation of
biocompatible ligands has further improved their selectivity, stability, and reduced toxicity, making them more suitable for clinical use. This review paper highlights the biomedical significance of coordination compounds in modern therapeutics, emphasizing their therapeutic potential,
mechanisms of action, and recent developments in metal-based drug design. The growing interdisciplinary approach, combining chemistry, biology, and medicine, suggests that coordination compounds will continue to make significant contributions to the development of next-generation therapeutic agents.

Keywords: Coordination compounds, Biomedical significance, Metal-based therapeutics, Anticancer drugs, Antimicrobial activity, Drug delivery systems, Medical imaging, Modern medicine.

Paper Title:: RECENT DEVELOPMENTS IN REDUCTIVE AMINATION: CATALYTIC STRATEGIES, MECHANISTIC INSIGHTS, AND SUSTAINABLE APPROACHES
Author Name:: Ingale Shivam Dnyaneshwar & Shobha Waghmode
Author Email:: shobhawaghmode@gmail.com
Country:: India
DOI:: https://doi.org/10.5281/zenodo.18604702
Page No.:: 16-23

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RECENT DEVELOPMENTS IN REDUCTIVE AMINATION: CATALYTIC STRATEGIES, MECHANISTIC INSIGHTS, AND SUSTAINABLE APPROACHES

Author: Ingale Shivam Dnyaneshwar & Shobha Waghmode

Abstract
Reductive amination is one of the most versatile and atom economical methods for forming carbon–nitrogen bonds directly from carbonyl compounds and amines. Over the past two decades, this transformation has evolved from classical stoichiometric reductions to highly selective, catalytic, and sustainable methodologies. This review discusses recent advances in metal-catalyzed hydrogenation, transfer hydrogenation, hydride-mediated, organocatalytic, photochemical, and electrochemical reductive amination
strategies. Emphasis is placed on catalyst design, mechanistic understanding, green reducing agents such as PMHS and formic acid, and the growing importance of sustainability. Computational studies and industrial applications are also highlighted to provide a comprehensive perspective on this rapidly developing field.

Keywords: Reductive amination; C–N bond formation; PMHS; SnCl₂·2H₂O; transfer hydrogenation; chemoselectivity; green chemistry; electrochemical reduction.

Paper Title:: MANNICH BASES OF 2-SUBSTITUTED BENZIMIDAZOLES
Author Name:: Shelar Vidya Sanjay & Shobha Waghmode
Author Email:: shobhawaghmode@gmail.com
Country:: India
DOI:: https://doi.org/10.5281/zenodo.18605383
Page No.:: 24-29

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MANNICH BASES OF 2-SUBSTITUTED BENZIMIDAZOLES

Author: Shelar Vidya Sanjay & Shobha Waghmode

Abstract
Mannich bases are the end products of mannich reaction and are known as beta amino ketone carrying compounds. Mannich reaction is a carbon carbon bond forming nucleophilic addition reaction which helps in synthesizing N-methyl derivatives and many other drug molecules. Mannich base derivatives of benzimidazoles possess many pharmacological properties such as anti-oxidant, anti-inflammatory, anticancer, antiviral,
anthelmintic and play an important role in medical field. As these drugs are clinically useful in treatment of microbial infections and exhibit other therapeutic activities also, so this encouraged the development of more potent, novel and clinically significant compounds. In this review synthesis and various biological activities of new mannich bases of benzimidazole derivatives reported is discussed.

Keywords: Mannich Bases, Substituted Benzimidazoles,
Pharmacological Activities.

Paper Title:: TRANSITION METAL COMPLEX CATALYSED MANNICH REACTION OF PHENOL
Author Name:: Kulkarni Neha Shekhar & Shobha Waghmode
Author Email:: sobhawaghmode@gmail.com
Country:: India
DOI:: https://doi.org/10.5281/zenodo.18617128
Page No.:: 30-35

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TRANSITION METAL COMPLEX CATALYSED MANNICH REACTION OF PHENOL

Author: Kulkarni Neha Shekhar & Shobha Waghmode

ABSTRACT
The mannich reaction is the most of the important carbon – carbon bond forming reactions in organic reactions . They involve the condensation of the aldehyde or ketones an amine. they forms as a beta amino carbonyl compound. Which is the important intermediate in pharmaceutical , or natural products, polymer chemistry. When combine with transition metal such as NI(II) , Cu(II), Co(II) these mannich bases ligand shows the stable
coordination complex with enhanced structural, catalytic and biological properties. This all-review focus on the synthesis , structural, catalytic behaviour of the transition metal complexesthey derived of the phenolic mannich bases. So, they contain the high purity solids with the good thermal stability.

Keywords:- In mannich reaction carbon carbon bond
formation product form beta amino ketone . Catalyst used :- Ni 2+ , Cu 2+, Co2+, Zn 2+. It enhanced catalytic properties.

Paper Title:: BIOINDICATORS: A KEY APPROACH TO ENVIRONMENTAL POLLUTION DETECTION
Author Name:: Hardeep Kaur
Author Email:: hardeepthind5@gmail.com
Country:: India
DOI:: https://doi.org/10.5281/zenodo.18655248
Page No.:: 36-42

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BIOINDICATORS: A KEY APPROACH TO ENVIRONMENTAL POLLUTION DETECTION

Author: Hardeep Kaur

ABSTRACT
The environment quality of water, soil and air is degraded increasingly. Therefore, it is essential to strengthen the prevention of pollution efforts by continuous monitoring of environmental quality. Biological methods evaluate
environmental quality by examining the presence and diversity of various organisms, including plants, insects, fish, bacteria and viruses which serve as bioindicators. Specific bacterial species have been served as biological indicators for monitoring environmental health. The bacteria act as an
indicator of household waste (human and animal faeces, household waste). Bioindicators refer to living organisms like planktons, plants, animals, and microorganisms, which are employed to determine the ecological status of the environment. They are utilized for evaluating environmental health and tracking biogeographical changes occurring in the ecosystems. All living entities within a biological system provide an insight into the quality of environment around them. In this review we have tried to explain the concept behind Bioindicators and plankton, with particular emphasis on their
potential to be used as Bioindicators for water quality assessment and outcomes relating to this.

Keywords: Ecosystems, Bioindicators, Pollution, Monitoring

Research & Reviews in Biotechnology and Biosciences

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Archives Volume: 13, Issue: 1, (January-June)

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